Cuddy really should've given House another chance - just look how sweet their off-spring would look like!!! :D:D:D

Johnny Depp - aka The Mad Hatter
Helena Bonham Carter - aka The Red Queen

a by product of the Alice in Wonderland Movie - sources, before and after

Seth Rogen and Katherine Heigl
Sources

Nancy Pelosi and Harry Reid mated (isn't there a saying about politicians making good bedfellows?).

hope you like

surce
sean connery: http://content.answers.com/main/content/img/getty/7/3/74434773.jpg
geore clooney: http://community.fxuk.com/blogs/fox_insider/george%20clooney.jpg

Megan Fox + Matt Damon = the fresh-faced, happy one above

she's so sexy
souces here:

click

Kate Moss & Pete Doherty... Pete was never more beautiful :)

Bond actors.